Zofran (generic name ondansetron) is primarily indicated for the prevention and treatment of nausea and vomiting.
Main uses include:
Chemotherapy-induced nausea and vomiting (CINV) – given before and sometimes after chemotherapy.
Radiation-induced nausea and vomiting (RINV) – to prevent nausea from radiation therapy.
Postoperative nausea and vomiting (PONV) – used before or after surgery to reduce nausea.
How it works: Zofran is a 5-HT₃ receptor antagonist. It blocks serotonin receptors in the brain and gut that trigger the vomiting reflex.
