Lactic acidosis

 Lactic acidosis is a type of metabolic acidosis that occurs when lactic acids build up in your blood.

Your body produces more lactate when your tissues are deprived of oxygen. 

Lactate can also build up if your livers and kidneys aren't able to metabolize it efficiently. Jun 13, 2023

What causes your lactic acid to be high?

Lactic acidosis occurs when lactic acid production exceeds lactic acid clearance. 

The increase in lactate production is usually caused by impaired tissue oxygenation, either from decreased oxygen delivery or a defect in mitochondrial oxygen utilization.

Be careful - lactate can be elevated by unrelated conditions. 

Even though lactate produced in the presence of sepsis may not necessarily be the result of widespread hypoperfusion,

 lactate can be an indicator that anaerobic metabolism is taking place. Therefore, lactate is sensitive to sepsis but not specific to sepsis.

Finally, stopping exercise and allowing lactate to clear is the surefire way to get rid of excess lactate. 

Your body naturally gets rid of lactic acid through metabolism. 

Taking deep breaths, staying hydrated, and reducing exercise intensity are the best ways to maximize natural lactate clearance.Jan 31, 2022

Drug screen panel test

https://www.testing.com/tests/10-panel-drug-testing/ 

A 10-panel drug test can detect recent use of 10 common drugs of abuse. The most common use is for workplace drug testing. Typically an employer may require drug testing for these reasons:

Pre-employment: This testing screens applicants for illegal drug use and is often conducted after a conditional offer of employment has been made.

Reasonable suspicion: Employers may conduct testing when drug use is suspected based on observable signs and symptoms in the workplace.

Post-accident: Drug testing may be performed after a workplace accident to determine if drug use may have been a contributing cause. Although you can test for recent drug use, a positive test alone cannot prove that drug use caused a specific accident.

Random: This type of drug testing is typically conducted without prior notice to act as a deterrent for employee drug use.

Periodic: Employers may elect to perform drug testing on a set schedule. Periodic testing may be administered as part of an annual physical exam.

Return-to-duty: This is performed when an employee is ready to return to the workplace after an extended absence. For example, it may be used after an employee has completed the required treatment for substance use following a positive result on a previous drug test.

Because the 10-panel drug test looks for more substances than many other drug tests, it is most frequently used by employers who want to screen employees for a wide range of substances.

What does the test measure?

The 10-panel drug test first analyzes the test sample, usually urine, for the residue of the following 10 substances:

1. Amphetamines Methamphetamines, meth, speed, ecstasy
2. THC Cannabinoids, marijuana, hash
3. Cocaine Coke, crack
4. Opiates Heroin, opium, codeine, morphine
5. Phencyclidine PCP, angel dust
6. Barbiturates Phenobarbital, butalbital, secobarbital
7. Benzodiazepines Diazepam, alprazolam, clonazepam
8. Methaqualone Quaaludes
9. Methadone Opiate analgesic
10. Propoxyphene Darvocet

If traces of these drugs are present in the initial screen, a second round of more precise testing is done to confirm the positive result.

In a urine drug test, additional analyses may be added to the tests for these 10 substances. For example, the lab may check the pH and other characteristics that help show that the urine sample was not adulterated, diluted, or substituted.

When should I get a 10-panel drug test?

An employer or potential employer may require you to get a 10-panel drug test before making a job offer, if they suspect you may have used illegal drugs, as part of a random or periodic drug testing program, or if you’ve been out of work due to an extended absence.

While 10-panel drug tests are most commonly used by employers, you may want to order a test for personal reasons. A 10-panel screen may be used for:

1. Medical screening: Your doctor may order a 10-panel drug test as part of your care.
2. Legal or forensic information: You may be required to take a drug test if you’ve been arrested or part of a surveillance program.
3. Sports/athletics testing: Some athletic competitions require drug testing prior to competing.
4. Monitoring pain medication use: A 10-panel drug test can be used to monitor your treatment and the level of any medications in your system.
5. A medical professional can help you determine when a 10-panel drug test is the right testing option for you.

What does a drug screening test consist of?

A drug test looks for signs of one or more illegal or prescription drugs in a sample of your urine (pee), blood, saliva (spit), hair, or sweat.

 The purpose of a drug test is to look for drug use and misuse, which includes: Using any illegal drugs, such as cocaine or club drugs.

What are the 12 panel drug tests?

A typical 12-Panel Urinalysis Drug Screen tests for active components in 10 different substances, including 

1. amphetamines, 
2. barbiturates, 
3. benzodiazepines, 
4. cannabis, 
5. cocaine,
6.  methadone, 
7. methaqualone, 
8. opioids,
9.  phencyclidine, and
10.  propoxyphene.

What shows up on a 5 panel drug test?

DOT 5 Panel Notice

Marijuana (THC)

Cocaine.

Amphetamines.

Opioids.

Phencyclidine (PCP)

Lipase Test enzyme for digestive system

 A lipase test is a blood test that looks for abnormal levels of the digestive enzyme lipase. It's a simple blood draw that you have in a doctor's office or lab. 

What does a high lipase level mean?  (reference and copy click the link) 

High lipase levels are often a sign of pancreatitis. Dec 15, 2023